In the field of Business Administration, Management and Corporate Governance, logistical bottlenecks and systemic external shocks disrupt supply continuity and erode manufacturing profitability. This empirical investigation systematically examines Digital Supply Chain Visibility, Operational Agility, and Disruption Resilience in Manufacturing Firms through a multi-stage experimental methodology and rigorous quantitative analytical framework. Utilizing partial least squares structural equation modeling (PLS-SEM) on 384 surveyed supply chain executives across ASEAN nations, data were gathered across multiple operational cycles and validated against established international benchmarks. The statistical and computational results reveal that end-to-end digital visibility enhanced operational agility (beta = 0.482, p < 0.001) and reduced disruption recovery lead times by 35%. Comparative sensitivity analyses confirmed a statistically significant improvement (p < 0.01) over conventional baseline approaches, with heightened reproducibility and robust fault tolerance. These comprehensive findings provide actionable theoretical insights and practical implementation guidelines for operations directors and enterprise supply chain digital transformation initiatives. Furthermore, the standardized protocols established in this study offer a valuable foundation for future cross-disciplinary investigations, policy formulation, and scalable technological deployment across global academic and industrial environments.