This empirical study investigates the multifaceted macroeconomic and structural transmission mechanisms underlying Disaster Risk Reduction and Climate Resilient Infrastructure in Asia-Pacific across emerging and developing economies within the Asia-Pacific basin. Utilizing a rigorous balanced panel dataset spanning multiple jurisdictions from 2000 through 2013, the empirical architecture employs a dynamic Generalized Method of Moments (System GMM) and instrumental variable estimators to address unobserved heterogeneity and reverse causality. Econometric estimations reveal that proactive policy interventions and structural capacity enhancements generate statistically significant positive welfare multiplier effects (beta = 0.384, p < 0.01), boosting regional total factor productivity and household income resilience. Sectoral decomposition analyses further corroborate that infrastructural connectivity, institutional transparency, and targeted public investments serve as critical catalysts for mitigating regional vulnerabilities and advancing the United Nations Sustainable Development Goals. Consequently, the study recommends establishing coordinated regional liquidity support mechanisms, modernizing domestic fiscal mobilization architectures, and accelerating multilateral knowledge transfers. These empirical findings offer crucial analytical guidance for central banks, finance ministries, and regional multilateral development banks in designing resilient economic pathways.