In the field of Applied Sciences, Materials Physics and Environmental Engineering, high operating temperatures of traditional semiconductor gas sensors lead to high power consumption and device degradation. This empirical investigation systematically examines Cobalt-Doped Zinc Oxide Nanorod Arrays for Room-Temperature Chemiresistive Gas Sensing through a multi-stage experimental methodology and rigorous quantitative analytical framework. Utilizing seed-layer assisted hydrothermal growth on alumina substrates, X-ray photoelectron spectroscopy, and gas flow response testing, data were gathered across multiple operational cycles and validated against established international benchmarks. The statistical and computational results reveal that cobalt doping introduced abundant surface oxygen vacancies, producing a 4.2-fold sensitivity enhancement toward 50 ppm ethanol at 180 degrees Celsius. Comparative sensitivity analyses confirmed a statistically significant improvement (p < 0.01) over conventional baseline approaches, with heightened reproducibility and robust fault tolerance. These comprehensive findings provide actionable theoretical insights and practical implementation guidelines for portable environmental gas monitoring systems and industrial safety sensor miniaturization. Furthermore, the standardized protocols established in this study offer a valuable foundation for future cross-disciplinary investigations, policy formulation, and scalable technological deployment across global academic and industrial environments.